Chimeric antigen receptor with novel intracellular modules improves antitumor performance of T cells
Abstract The excessive cytokine release and limited persistence represent major challenges for chimeric read more antigen receptor T (CAR-T) cell therapy in diverse tumors.Conventional CARs employ an intracellular domain (ICD) from the ζ subunit of CD3 as a signaling module, and it is largely unknown how alternative CD3 chains potentially contribu